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Allergic reaction to Frontline Plus

Our dog had an allergic reaction to Frontline Plus. He broke out in welts and sores.

The vet prescribed prednisone and tonight he is panting like crazy, in addition to drinking and urinating frequently. The vet mentioned that panting might be a side effect but I am worried he is panting so fast.

Is there any concern with it progressing to a heart attack or other worse issue? The prednizone did seem to help the skin, but the panting is frightening.



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107 Responses to “Allergic reaction to Frontline Plus”

  1. Robert Festinger says:

    while i was using frontline plus i faced the same problem with my boxer dog, he had fiver for 3-4 days as soon as frontline plus applied to it, so my vet told me that may be frontline plus is not for him, so he suggested me aspis forte i.t generic version of frontline plus by his experience, he told me that this could help me, and really it worked as well as no other harmful side effects.

  2. Robin says:

    Hello Christine with the chihuahua!
    How is your dog doing now almost 3 months later? My little dog is having the identical symptoms as yours and she received frontline a week ago. She is lethargic, was running a fever which has subsided. Her white blood cell count is dangerously LOW. We cannot figure out what is wrong with her, but she seems soooo lethargic and she is usually the peppy one.

  3. Jasmine says:

    Hello Robin and Christine! My dog is have the same symptoms, she can’t walk on her back right leg, won’t eat or drink, is running a fever. This is not like her at all she is always very happy and I don’t know what to do :(. She recieved frontline about 3 and a half weeks ago.

  4. Kirk says:

    My dog and I encountered the red bumps, rash, skin irritation and itch to my dog that appeared around his body – 10 month malamute.
    The vet was resistant to acknowledging any correlation between the rash and frontline. My dog ended up chewing his back end raw trying to relieve the itch. He is now wearing a cone for the next three weeks, on antibiotics, and a course of topical ointnment on the sores.
    Spent two weeks trying to find a common cause behind allergic reaction before reading the posts here that described his symptoms.

  5. Mary says:

    My poor Ashton is a Chinese Shar Pei after I put on the frontline plus skin bubbled like a burn. She has a permanent scar on her back with no hair growing back in. She was so sick took several vet visits to get her back on track. No more for me!!!

  6. Louise says:

    Hi all. I realize that your posts are quite old now, but some of the things you mentioned could be from LYME DISEASE, particularly the dog who couldn’t walk on one of her legs and was so lethargic. Yes, Frontline COULD be the cause of all of this, but BEWARE, Lyme disease is a serious possibility, anywhere there are ticks…… and that is almost everywhere. Many of my dogs’ symptoms were attributed to other causes, but then, when tested, the dogs came up positive for Lyme. When treated for Lyme (a long course of antibiotics), the symptoms mostly went away, regardless of which topical flea product I used. Just a thought. One of my dogs scratches terribly from fleas, and just as badly when Frontline is used. However, he does not get a rash from Frontline. He DOES get a rash and welts from Advantix.

  7. Cristina says:

    Hiya, I’m always worried about frontline and will try and use herbal where possible. The product that has caused the worst effect to my two yorkies is milbemax which nearly killed them, they both now have judders brought on by milbemax attacking their nervous system and noise causes them to fall over, they both have gone bold, have fits and sunnie now has heart problems. I never advise anyone to use this and stay away as I only know as both my dogs are suffering

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